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Cold Medicine Without Dextromethorphan DM: Guaifenesin Only

Cold Medicine Without Dextromethorphan DM: Guaifenesin Only

Joe "head xeteorologist" at xeteor.com Joe "head xeteorologist" at xeteor.com
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UPDATE: October 6th, 2024

Rugby Mucus & Chest Congestion Guaifenesin 200 mg Cough Syrup is back! This popular cough syrup had been unavailable for the past 6 months.  It contains Guaifenesin 200 mg ONLY with no Dextromethorphan.

Rugby Chest Congestion & Mucus Guaifenesin 200 mg Cherry Flavor - 4 Fl Oz

Rugby Chest Congestion & Mucus Guaifenesin 200 mg Cherry Flavor - 4 Fl Oz

$9.99

Rugby Chest Congestion & Mucus Guaifenesin 200 mg Cherry Flavor - 4 Fl Oz Guaifenesin, USP 200 mg per 10 mL Expectorant Cherry Flavored For...… read more


Coughs can be annoying and disruptive, but luckily there are effective over-the-counter cough medicines available. Many popular cough syrups contain additional ingredients like dextromethorphan (DM), but some people prefer to avoid DM and use only guaifenesin especially to avoid interactions with other medications or unwanted side-effects. While these medications are readily available in tablet form, finding liquid guaifenesin only cough syrups can be difficult.  Below, we explore options for people looking for cold medicine without dextromethorphan or other ingredients such as phenylephrine or pseudoephedrine.

Cold Medicine Without Dextromethorphan

Cold Medicine Without Dextromethorphan (DM)

What is Guaifenesin?

Guaifenesin is an expectorant that helps thin mucus secretions and make coughs more productive. By thinning mucus, guaifenesin helps loosen phlegm and bronchial secretions, making it easier to cough them up. This provides temporary relief from wet, mucus-y coughs.

Guaifenesin works by drawing more water into the bronchial passages. This thins out the mucus, allowing it to be coughed up more easily. Guaifenesin does not suppress the cough reflex like DM cough medicines. Instead, it targets the root cause - the excess mucus production.

Why Avoid Dextromethorphan (DM)?

Some people want to avoid dextromethorphan (DM) for the following reasons:

  • DM can cause side effects like drowsiness, dizziness, nausea
  • DM should not be used by people taking certain medications that can interact with it. Examples include MAO inhibitors like phenelzine and tranylcypromine; SSRIs like fluoxetine and paroxetine; and tricyclic antidepressants like amitriptyline and imipramine.
  • DM only temporarily suppresses coughs and does not treat the underlying mucus production
  • Once DM wears off, the cough can return

Guaifenesin is a good option for people who want to avoid DM. It specifically targets mucus production to more fully relieve coughs.

cold medicine without dextromethorphan

When to Use Guaifenesin

Guaifenesin-only cough syrups work best for wet, productive coughs where excess mucus is an issue. Some examples include:

  • Coughs from minor upper respiratory infections like the common cold or flu
  • Coughs from sinus drainage
  • Coughs related to mild bronchitis
  • Coughs with chest congestion and excess phlegm

Guaifenesin helps temporarily relieve these mucus-related coughs by making it easier to cough up phlegm. This provides better airway clearance.

Look for guaifenesin on the active ingredient label of over-the-counter cough syrups. Use guaifenesin-only products to get effective relief from wet, mucus-filled coughs without the downsides of DM. The expectorant action of guaifenesin makes it easier to clear excess phlegm and soothe coughs naturally.

Best Cold Medicine Without Dextromethorphan - Cough Syrups

Below are the three products we recommend as they are generally available and are high quality generics manufactured by trusted brands.

1. Rugby Mucus & Chest Congestion Guaifenesin 200 mg Cough Syrup

Rugby Mucus & Chest Congestion Guaifenesin 200 mg cough syrup had been unavailable for the past 6 months but is back in stock as of October 6th, 2024.  This cough syrup comes in cherry flavor and was by far the most popular brand for Guaifenesin only cough syrups, before it became unavailable. It's also the same product as Major Robafen Congestion Formula which is its popular cousin as Major and Rugby are the same company. 

Rugby Mucus & Chest Congestion Guaifenesin 200 mg Cough Syrup

Active Ingredient: Guaifenesin USP 200 mg

Inactive Ingredients: Anhydrous Citric Acid, Caramel, FD&C Red no. 40, Flavor, Glycerin, High Fructose Corn Syrup, Menthol, Propylene Glycol, Purified Water, Saccharin Sodium, Sodium Benzoate



2. Foster & Thrive Adult Tussin Guaifenesin 200 mg Expectorant Cough Syrup no Dextromethorphan (DM)

Foster & Thrive, a new brand by McKesson, consolidates the Sunmark and Healthmart brands.  Foster & Thrive is dedicated to providing high-quality healthcare products at an exceptional value. Their focus is on transparency, quality, and affordability, ensuring customers have access to reliable health products without unnecessary costs. Foster & Thrive's range includes over-the-counter medications and wellness products, all developed with a commitment to fostering better health outcomes.

Foster & Thrive Adult Tussin Guaifenesin 200 mg Expectorant Cough Syrup - 4 fl oz (Robitussin)

Foster & Thrive Adult Tussin Guaifenesin 200 mg Expectorant Cough Syrup - 4 fl oz | Robitussin

Foster & Thrive is a new brand by McKesson that offers an excellent Guaifenesin cold medicine without dextromethorphan.  It comes in a 4 fl oz bottle and does not contain Dextromethorphan (DM). If you are a fan of Major Robafen Congestion Formula or Rugby Mucus & Chest Congestion Cough Syrup (back in stock as of 10-6-2024) this is a perfect choice as it contains the same active and inactive ingredients as those two products. This product does not contain propylene glycol for those with allergies.

Active Ingredient: Guaifenesin 200 mg

Inactive Ingredients: Caramel, citric acid anhydrous, dextrose, FD&C red #40, flavor, glycerin, high fructose corn syrup, menthol, purified water, saccharin sodium, sodium benzoate.

Drug Facts Label: Foster & Thrive Adult Tussin Guaifenesin 200 mg Expectorant Cough Syrup - 4 fl oz (Robitussin)

Foster & Thrive Adult Tussin Guaifenesin 200 mg Expectorant Cough Syrup sells for $9.99. You can purchase 2 bottles for $17.98 ($8.99 per bottle) and 3 bottles for $19.98 ($6.66 per bottle) to maximize your savings and order it from xeteor.com with fast free shipping nationwide and free next day shipping in Las Vegas, Nevada.

3. Rugby Laboratories Guaifenesin Oral Solution with no Dextromethorphan (DM)

Rugby Chest Congestion Relief Guaifenesin Oral Solution Cherry Flavor - 16 Fl Oz (Robitussin)

Rugby Chest Congestion Relief Guaifenesin Oral Solution Cherry Flavor - 16 Fl Oz | Robitussin

Currently the only Rugby or Major brand Guaifenesin cold medicine without dextromethorphan available is Rugby's Cherry Flavored Chest Congestion Relief Guaifenesin Oral Solution.  It comes in a 16 fl oz bottle and does not contain Dextromethorphan (DM).

Active ingredient: Guaifenesin 100 mg

Inactive ingredients: Artificial and natural cherry flavor, Citric Acid, FD&C Red #40, Menthol, Methylparaben, Propylene Glycol, Propylparaben, Purified Water, Sodium Citrate, Sucralose

Rugby Chest Congestion Relief Guaifenesin Oral Solution Cherry Flavor - 16 Fl Oz (Robitussin)

Rugby Chest Congestion Relief Guaifenesin Oral Solution sells for $16.99. You can purchase 2 bottles for $19.98 ($9.99 per bottle) and 3 bottles for $26.97 ($8.99 per bottle) to maximize your savings and order it from xeteor.com with fast free shipping nationwide and free next day shipping in Las Vegas, Nevada.

Best Cold Medicine Without Dextromethorphan - Tablets

If you don't mind taking your Guaifenesin in tablet form, there are a few options from both Major Pharmaceuticals & Rugby Laboratories.

1. Major Guaifenesin 200 mg - 100 Tablets with No Dextromethorphan (DM)

Rugby Chest Congestion Relief Guaifenesin Oral Solution Cherry Flavor - 16 Fl Oz (Robitussin)

Major Guaifenesin 200 mg - 100 Tablets | Mucinex

Major Guaifenesin 200 mg comes in 100 immediate release tablets. It's a simple solution in tablet form. 

Active ingredient: Guaifenesin 200 mg

Inactive ingredients: Magnesium Stearate, Maltodextrin, Microcrystalline Cellulose, Povidone K30, Povidone 90F, Silicon Dioxide, Stearic Acid

2. Rugby Chest Congestion Relief Guaifenesin 400 mg - 60 Tablets with No Dextromethorphan (DM)

Rugby Chest Congestion Relief Guaifenesin Oral Solution Cherry Flavor - 16 Fl Oz (Robitussin)

Rugby Chest Congestion Relief Guaifenesin 400 mg - 60 Tablets | Mucinex

Rugby Chest Congestion Relief Guaifenesin 400 mg comes in 60 immediate release tablets. It's slightly stronger than the Major version, but again a very simple solution in tablet form with no dextromethorphan. 

Active ingredient: Guaifenesin 400 mg

Inactive ingredients: Magnesium Stearate, Maltodextrin, Microcrystalline Cellulose, Povidone K30, Povidone 90F, Silicon Dioxide, Stearic Acid 

Discontinued Cough Syrup with No Dextromethorphan (DM)

Major Robafen Congestion Formula - 4 fl oz (Robitussin)

Major Robafen Congestion Formula - 4 fl oz (Robitussin)

This product is the most popular Major guaifenesin cold medicine without dextromethorphan, but unfortunately, it's backordered.  Major Pharmaceuticals hasn't given us an estimated date when it will be in stock, however, you can sign up to be notified (click big red button).

A perfect popular alternative is Rugby Mucus & Chest Congestion Guaifenesin 200 mg Cough Syrup which is the same product and is available again as of October 6th, 2024.  Major Pharmaceuticals & Rugby Laboratories are the same company based in Livonia, Michigan. 

Active Ingredient: Guaifenesin USP 200 mg

Inactive Ingredients: Anhydrous Citric Acid, Caramel, FD&C Red no. 40, Flavor, Glycerin, High Fructose Corn Syrup, Maltol, Menthol, Propylene Glycol, Purified Water, Saccharin Sodium, Sodium Benzoate


Rugby Mucus & Chest Congestion Cherry Flavor - 4 Fl Oz

Rugby Mucus & Chest Congestion Cherry Flavor - 4 Fl Oz

This product is the most popular Rugby guaifenesin cold medicine without dextromethorphan, but unfortunately, it's backordered. Rugby Laboratories hasn't given us an estimated date when it will be in stock, however, you can sign up to be notified (click big red button).

Active Ingredient: Guaifenesin USP 200 mg

Inactive Ingredients: Anhydrous Citric Acid, Caramel, FD&C Red no. 40, Flavor, Glycerin, High Fructose Corn Syrup, Menthol, Propylene Glycol, Purified Water, Saccharin Sodium, Sodium Benzoate

NOTE: This product is available as of October 6th, 2024.


See a full list of Major and Rugby Cough Syrups including those with Dextromethorphan (DM) and Phenylephrine (PE).

Products Mentioned in this Blog Post

Rugby Chest Congestion & Mucus Guaifenesin 200 mg Cherry Flavor - 4 Fl Oz

Rugby Chest Congestion & Mucus Guaifenesin 200 mg Cherry Flavor - 4 Fl Oz

$9.99

Rugby Chest Congestion & Mucus Guaifenesin 200 mg Cherry Flavor - 4 Fl Oz Guaifenesin, USP 200 mg per 10 mL Expectorant Cherry Flavored For...… read more

Foster & Thrive Adult Tussin Guaifenesin 200 mg Expectorant Cough Syrup - 4 fl oz | Robitussin

Foster & Thrive Adult Tussin Guaifenesin 200 mg Expectorant Cough Syrup - 4 fl oz | Robitussin

$9.99

Foster & Thrive Adult Tussin Guaifenesin 200 mg Expectorant Syrup - 4 fl oz | Robitussin Mucus + Chest Congestion Foster & Thrive, a McKesson's...… read more

Rugby Chest Congestion Relief Guaifenesin Oral Solution Cherry Flavor - 16 Fl Oz | Robitussin

Rugby Chest Congestion Relief Guaifenesin Oral Solution Cherry Flavor - 16 Fl Oz | Robitussin

$12.99

Helps loosen phlegm (mucus) and thin bronchial secretions to make coughs more productive. Rugby Chest Congestion Relief Guaifenesin Oral Solution Cherry Flavor - 16 Fl...… read more

Rugby Chest Congestion Relief Guaifenesin 100mg Cough Syrup | Robitussin (3 Pack)

Rugby Chest Congestion Relief Guaifenesin 100mg Cough Syrup | Robitussin (3 Pack)

$29.97

Rugby Chest Congestion Relief Guaifenesin 100mg Cough Syrup - 16 fl oz | Robitussin (3 Pack) Cherry Menthol - Is That Even a Real Flavor?...… read more

Rugby Chest Congestion Relief Guaifenesin 100mg Cough Syrup | Robitussin (4 Pack)

Rugby Chest Congestion Relief Guaifenesin 100mg Cough Syrup | Robitussin (4 Pack)

$39.99

Rugby Chest Congestion Relief Guaifenesin 100mg Cough Syrup - 16 fl oz | Robitussin (4 Pack) Cherry Menthol - Is That Even a Real Flavor?...… read more

Major Guaifenesin 200 mg - 100 Tablets | Mucinex

Major Guaifenesin 200 mg - 100 Tablets | Mucinex

$8.99

Major Immediate Release Guaifenesin 200 mg - 100 Tablets | Mucinex Key Features Works like Mucinex Guaifenesin 200 mg Expectorant 100 immediate release tablets Expiration...… read more

Rugby Chest Congestion Relief Guaifenesin 400 mg - 60 Tablets | Mucinex

Rugby Chest Congestion Relief Guaifenesin 400 mg - 60 Tablets | Mucinex

$7.99

Rugby Chest Congestion Relief - 60 Tablets | Dye-Free Mucinex Key Features Works like Mucinex SE Guaifenesin, 400 mg Dye-Free Expectorant 60 immediate release tablets...… read more

Rugby Chest Congestion Relief Guaifenesin 400 mg - 60 Tablets | Mucinex (3 Pack)

Rugby Chest Congestion Relief Guaifenesin 400 mg - 60 Tablets | Mucinex (3 Pack)

$16.98

Rugby Chest Congestion Relief Guaifenesin 400 mg - 60 Tablets | Dye-Free Mucinex SE (3 Pack) What will I receive? 3 bottles of Rugby Chest...… read more

About xeteor.com

xeteor.com, started in 2018 is based in Las Vegas, Nevada and is online pharmacy focusing on discount over-the-counter generic medications, like cold medicine without dextromethorphan and diabetic test strips. We find deals normally reserved for "big pharma" and offer them to the consumer at discount prices. Ranking as the #1 authorized online reseller of Major Pharmaceuticals & Rugby Laboratories products according to Trustpilot.com, xeteor.com has 8,000+ 5-star reviews online, including Amazon, eBay, Trustpilot, and Google. xeteor.com is a Google Top Quality Store, earned by merchants that provide a great shopping experience.

Shipping Time & Cost

All items ship same day when purchased by 3 pm PST Monday - Friday. We offer free shipping nationwide with no minimum order. Shipping times are between 3 to 8 business days, with an average of 3.3 business days. A link to our full shipping policy is here.

Payment Options

We offer multiple convenient payment options, including Visa, Mastercard, Discover, American Express, Google Pay, Apple Pay, PayPal and Venmo.

Return Policy

We offer a 100% satisfaction guarantee. If you are not satisfied with the product, you may return it up to 100 days from the date of purchase. We offer free return shipping to ensure you can try the product risk free. A link to our full return policy is here.

How to Reach Us?

If you have questions about the product or need assistance, we are happy to talk on the phone. Call us at 1-833-787-4777 between 9 am - 5 pm PST Monday - Friday. You can also email us at [email protected] or text us at 702-659-7022. A link to our full contact us page is here.

Disclaimer: This post is intended for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your doctor or another qualified health provider with any questions you may have regarding a medical condition or before starting any new treatment. Do not disregard professional medical advice or delay in seeking it because of something you have read in this post.

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