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Capsaicin Cream for Neuropathy & Arthritis

Capsaicin Cream for Neuropathy, Arthritis & More

Joe Joe "head xeteorologist" at xeteor.com
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Capsaicin Cream for Neuropathy & Arthritis: How It Compares to Menthol, Lidocaine, and Diclofenac Creams

Capsaicin cream has gained popularity as a topical pain reliever, especially for conditions like nerve pain, arthritis, and even some less conventional uses like nausea relief. But how does it actually work, and how does it stack up against better-known options like menthol, lidocaine, and diclofenac creams? Let’s dive into the science, compare the benefits, and help you choose the right solution for your specific needs.


How Capsaicin Cream Works

What Is Capsaicin Cream?

Capsaicin is the active component in chili peppers that causes a burning sensation. When used topically, capsaicin cream helps reduce pain by depleting a neurotransmitter called substance P, which is involved in transmitting pain signals to the brain. It doesn't work immediately like menthol or lidocaine; instead, it builds effectiveness over a week or two of consistent use.

Capsaicin creams typically come in two strengths:

  • 0.025% for mild to moderate pain
  • 0.075% or higher for more stubborn nerve pain
  • 0.1% for severe or persistent nerve pain, often used under medical supervision

Capsaicin Cream Burning Skin


Capsaicin Cream for Neuropathy

Capsaicin Cream for Neuropathy

Topical capsaicin is often used for peripheral neuropathy, especially diabetic nerve pain and postherpetic neuralgia (shingles-related pain). According to clinical research, regular application can help reduce tingling, burning, and shooting pains by gradually desensitizing the nerves.

Pros:

  • Non-systemic (no impact on liver or kidneys)
  • Can be applied directly to pain sites
  • Well-tolerated for long-term use

Cons:

  • Initial burning or stinging sensation
  • Requires consistent application for 1–2 weeks before effects are felt

Capsaicin Cream for Arthritis

Capsaicin Cream for Arthritis

Capsaicin cream can also relieve pain from osteoarthritis, particularly in the knees and hands. Unlike NSAIDs, it doesn't reduce inflammation but instead alters how the nerves perceive pain. This makes it a solid choice for those who can't tolerate oral pain medications.

Tip: Apply after warming up joints (e.g., post-shower or light movement) for enhanced effectiveness.


Capsaicin Cream for Nausea

Capsaicin Cream for Nausea?

While not a common use, there's emerging research suggesting capsaicin may reduce nausea in chemotherapy patients when applied to the skin. The proposed mechanism is sensory distraction: by stimulating nerve endings in the skin, capsaicin may help override nausea signals. This is still experimental and not FDA-approved for this use.

Always consult a healthcare provider before using capsaicin cream for nausea.


How Capsaicin Compares to Other Topical Pain Relievers

Cream TypeActive IngredientBest ForPopular BrandsNotes
CapsaicinCapsaicin 0.025–0.075%Nerve pain, arthritisZostrix, RugbyRequires consistent use, burning sensation
MentholMenthol, Camphor, Methyl SalicylateMuscle aches, coolingIcy Hot, Bengay, RugbyFast-acting but short-lived
LidocaineLidocaine 4–5%Localized nerve painSalonpas, AspercremeNumbs pain instantly, temporary relief
DiclofenacNSAID (1%)Arthritis, inflammationVoltarenReduces inflammation, takes time to work

Zostrix vs Rugby Capsaicin Cream - Is the generic version just as good?


When to Choose Each Type

What is Capsaicin Cream Used For

Capsaicin: Best for chronic nerve pain or arthritis where long-term relief is the goal

Capsaicin Cream vs Menthol Creams

Menthol / Methyl Salicylate / Camphor: Great for short-term muscle relief and a cooling effect

Capsaicin Cream vs Lidocaine Cream

Lidocaine: Ideal for shingles, nerve blocks, or sore spots needing fast numbing

Capsaicin Cream vs Diclofenac Sodium

Diclofenac: Most effective for inflammatory arthritis and joint swelling


Side Effects to Watch Out For

  • Capsaicin: Burning, stinging, redness. Avoid touching eyes or mucous membranes.
  • Menthol/Camphor: Cooling or warming sensations; occasional rash.
  • Lidocaine: Numbness, rare allergic reactions.
  • Diclofenac: Dry skin, irritation, potential systemic effects with long-term use.

Final Thoughts

Capsaicin cream may not deliver instant results, but it’s one of the few topical products that works by changing how your body feels pain, rather than masking it. Whether you’re dealing with diabetic nerve pain, arthritis, or simply want a non-pill alternative, capsaicin is worth considering.


Products Mentioned in this Blog Post

Rugby Capsaicin Cream 0.025% - 2 oz | Zostrix

Rugby Capsaicin Cream 0.025% - 2 oz | Zostrix

$6.99

Rugby Capsaicin Cream 0.025% – 2 oz | Zostrix Alternative Rugby Capsaicin Cream 0.025% is a topical pain relief cream made with capsaicin — a...… read more

Rugby Capsaicin Cream 0.025% - 2 oz | Zostrix (3 Pack)

Rugby Capsaicin Cream 0.025% - 2 oz | Zostrix (3 Pack)

$17.97

Rugby Capsaicin Cream 0.025% – 2 oz (3 Pack) | Zostrix Alternative Only $17.97 for 3 boxes – that’s just $5.99 per 2 oz tube!...… read more

Rugby Capsaicin Cream 0.025% - 2 oz | Zostrix (4 Pack)

Rugby Capsaicin Cream 0.025% - 2 oz | Zostrix (4 Pack)

$22.96

Rugby Capsaicin Cream 0.025% – 2 oz (4 Pack) | Zostrix Alternative Only $22.96 for 4 boxes – that’s just $5.74 per 2 oz tube!...… read more

Rugby Arthritis Pain Relieving Cream - 2 oz | Zostrix HP

Rugby Arthritis Pain Relieving Cream - 2 oz | Zostrix HP

$7.99

Rugby Arthritis Pain Relieving Cream – 0.075% Capsaicin - 2 oz | Zostrix HP Alternative Rugby Arthritis Pain Relieving Cream is a high-potency topical analgesic...… read more

Rugby Arthritis Pain Relieving Cream - 2 oz | Zostrix HP (2 Pack)

Rugby Arthritis Pain Relieving Cream - 2 oz | Zostrix HP (2 Pack)

$14.98

Rugby High Potency Arthritis Pain Relieving Cream – 0.075% Capsaicin - 2 oz (2 Pack) | Zostrix HP Alternative Only $14.98 for 2 boxes –...… read more

Rugby Arthritis Pain Relieving Cream - 2 oz | Zostrix HP (3 Pack)

Rugby Arthritis Pain Relieving Cream - 2 oz | Zostrix HP (3 Pack)

$18.99

Rugby High Potency Arthritis Pain Relieving Cream – 0.075% Capsaicin - 2 oz (3 Pack) | Zostrix HP Alternative Only $18.99 for 3 boxes –...… read more

Rugby Muscle Rub Cream - 3 oz | Bengay

Rugby Muscle Rub Cream - 3 oz | Bengay

$6.99

Rugby Muscle Rub Cream – 3 oz | Compare to Bengay Rugby Muscle Rub Cream (3 oz) is a greaseless, fast-absorbing topical analgesic that delivers...… read more

Rugby Maximum Strength Pain Relieving Cream - 3 oz | Thera-Gesic

Rugby Maximum Strength Pain Relieving Cream - 3 oz | Thera-Gesic

$6.99

Rugby Maximum Strength Pain Relieving Cream – 3 oz | Generic for Thera-Gesic Rugby Maximum Strength Pain Relieving Cream offers fast-acting relief for minor muscle...… read more

Oncor Lidocaine Cream 4% - 1.05 oz | Aspercreme

Oncor Lidocaine Cream 4% - 1.05 oz | Aspercreme

$11.99

Oncor Lidocaine 4% Cream – Topical Anesthetic for Pain Relief Fast-Acting Relief for Everyday Skin DiscomfortOncor Lidocaine 4% Cream is a powerful topical anesthetic designed...… read more

Rugby Diclofenac Sodium Gel 1% - 3.53 oz | Voltaren (4 Pack)

Rugby Diclofenac Sodium Gel 1% - 3.53 oz | Voltaren (4 Pack)

$49.96

Rugby Diclofenac Sodium Topical Gel 1% - 3.53 oz | Voltaren (4 Pack) Google Says to Eat at Least One Small Rock per Day (Don't...… read more

Always talk to a healthcare provider before starting any new treatment, especially if you have sensitive skin, allergies, or chronic health conditions.

About xeteor.com

xeteor.com, started in 2018 is based in Las Vegas, Nevada and is online pharmacy focusing on discount over-the-counter generic medications and diabetic test strips. We find deals normally reserved for "big pharma" and offer them to the consumer at discount prices. Ranking as the #1 authorized online reseller of Major Pharmaceuticals & Rugby Laboratories products according to Trustpilot.com, xeteor.com has 8,000+ 5-star reviews online, including Amazon, eBay, Trustpilot, and Google. xeteor.com is a Google Top Quality Store, earned by merchants that provide a great shopping experience.

Shipping Time & Cost

All items ship same day when purchased by 3 pm PST Monday - Friday. We offer free shipping nationwide with a $30 minimum order; however, we offer savings packs which ship free. Shipping times are between 3 to 8 business days, with an average of 3.3 business days. A link to our full shipping policy is here.

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Return Policy

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How to Reach Us?

If you have questions about the product or need assistance, we are happy to talk on the phone. Call us at 1-833-787-4777 between 9 am - 5 pm PST Monday - Friday. You can also email us at [email protected] or text us at 702-659-7022. A link to our full contact us page is here.

Disclaimer: This post is intended for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your doctor or another qualified health provider with any questions you may have regarding a medical condition or before starting any new treatment. Do not disregard professional medical advice or delay in seeking it because of something you have read in this post.

FAQs

What is capsaicin cream used for?

Capsaicin cream is a topical pain reliever used to reduce discomfort from nerve pain (like diabetic neuropathy or shingles), arthritis, muscle aches, and joint pain. It works by depleting substance P, a chemical that helps transmit pain signals.

How long does it take for capsaicin cream to work?

Relief typically builds gradually. Most people begin noticing reduced pain after 1–2 weeks of consistent use, with full effects in 2–4 weeks. It’s important to apply it 3 to 4 times daily as directed.

Is capsaicin cream safe to use every day?

Yes. Capsaicin cream is safe for daily, long-term use when applied as directed. Because it doesn’t enter the bloodstream, it avoids many side effects associated with oral pain medications. However, avoid applying it to broken or irritated skin.

What are the side effects of capsaicin cream?

The most common side effect is a burning or stinging sensation at the application site, especially during the first few days. This usually lessens with continued use. Less commonly, redness or irritation may occur. Always wash hands thoroughly after applying.

What’s the difference between Zostrix and generic capsaicin cream?

Zostrix is a brand-name capsaicin cream, while generic versions—like Rugby Capsaicin Cream—contain the same active ingredient (usually 0.025%) at a more affordable price. Generics work just as effectively for most people and are often preferred for long-term use.

Can I use capsaicin cream for shingles or nerve pain?

Yes. Capsaicin cream is commonly used to relieve nerve pain caused by shingles (postherpetic neuralgia) and other types of neuropathy. It won’t cure the condition but can help reduce burning, tingling, and shooting pain when used regularly.

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