Major Nasal Decongestant Spray vs Afrin: What’s the Difference?
Table of Contents
- Same Active Ingredient, Same Relief
- Price Showdown — Brand vs Generic
- Compare Major Nasal Spray Pack Sizes
- Not Ready for a 24-Pack?
- Prefer a Squeeze Bottle?
- Safety & Usage Tips
- Bottom Line: Same Medicine, Better Price
- Major Nasal Decongestant Spray vs Afrin: Final Comparison
- Products Mentioned in This Blog Post
- About xeteor.com
- FAQs
Major Nasal Decongestant Spray vs Afrin is one of the most-searched comparisons among nasal sprays today. Both use the same proven decongestant—oxymetazoline HCl 0.05 %—to shrink swollen nasal passages and clear congestion fast. But when it comes to price, the difference is dramatic. Below you’ll find a head-to-head breakdown of ingredients, price per ounce, and pack-size options, so you can choose the smartest deal for your medicine cabinet. It’s a smart alternative that more people are choosing.
When cold or allergy season strikes, choosing the right nasal spray can make a big difference. If you're comparing Major Nasal Decongestant Spray vs Afrin, you're not alone. Many shoppers are looking for affordable alternatives that still deliver fast, long-lasting relief. Below, we break down what you need to know—so you can save smart without sacrificing quality.
Same Active Ingredient, Same Relief
- Oxymetazoline Hydrochloride 0.05% in both Afrin® and Major
- Works in minutes and lasts up to 12 hours
- No-drip formula for comfortable, mess-free use
- Relieves congestion from colds, allergies, and sinus pressure
Price Showdown — Brand vs Generic
The biggest difference? Cost per fluid ounce. Afrin’s common retail size is a 0.5 fl oz bottle. Our best-value pack is a 1 fl oz bottle, sold in bulk. Here’s how they stack up:
| Product | Pack Details | Total Fl Oz | Price | Price / Ounce |
|---|---|---|---|---|
| Afrin® — 3-Pack (0.5 fl oz each) | 0.5 fl oz × 3 | 1.5 fl oz | $26.99 | $17.99 |
| Major Nasal Spray — 24-Pack (1 fl oz each) | 1 fl oz × 24 | 24 fl oz | $69.99 | $2.92 |
*Prices verified June 26, 2025. Afrin listing sold by Amazon; prices may change.
That’s over 16× more spray for about the same price. Even if you don’t need that much right now, the 24-pack is ideal for clinics, large families, or splitting among friends to save big.
Compare Major Nasal Spray Pack Sizes
| Product | Fl Oz | Price | Per Ounce |
|---|---|---|---|
| Single – 1 fl oz | 1 | $5.99 + $4.99 ship | $5.99 |
| 5-Pack – 1 fl oz | 5 | $18.95 | $3.79 |
| 15-Pack – 1 fl oz | 15 | $48.99 | $3.27 |
| 24-Pack – 1 fl oz | 24 | $69.99 | $2.92 |
†Shipping is free on all multi-packs and orders over $30. Single bottles under $30 add $4.99 shipping.
Not Ready for a 24-Pack?
If you’d prefer to start smaller, we carry every size of the Major 1 fl oz nasal spray:
- Single 1 fl oz – $5.99 + $4.99 ship
- 5-Pack 1 fl oz – $18.95 (Free Shipping)
- 15-Pack 1 fl oz – $48.99 (Free Shipping)
Prefer a Squeeze Bottle?
Most nasal sprays, including our 1 fl oz Major packs, use a pump-style applicator. But if you prefer the classic squeeze bottle design, we also carry Major’s 0.5 fl oz option:
- Single 0.5 fl oz Squeeze Bottle – $5.99 + $4.99 ship
- 2-Pack – $9.99 (Free Shipping)
- 5-Pack – $17.99 (Free Shipping)
Note: The 0.5 fl oz squeeze bottle offers the same active ingredient and relief, just in a different applicator format some users find easier to control.
Safety & Usage Tips
Oxymetazoline is effective, but overuse can lead to rebound congestion. Follow these usage guidelines for best results:
- Adults & kids 6+: 2–3 sprays per nostril every 10–12 hours
- Do not use more than 3 consecutive days to avoid rebound congestion
- Shake, prime, and keep the nozzle clean between uses
- Store the bottle upright in a cool, dry place, and keep the cap tightly closed to avoid contamination.
Bottom Line: Same Medicine, Better Price
When it’s Major Nasal Decongestant Spray vs Afrin, the only real difference is the label — unless you count the savings. With Major, you get the same active ingredient, same relief, and a much better price — especially in the 24-pack.
Disclaimer: Information provided for educational purposes. Consult your healthcare provider before using any nasal decongestant if you have heart disease, high blood pressure, thyroid disease, diabetes, or are pregnant.
Major Nasal Decongestant Spray vs Afrin: Final Comparison
To sum it up, both sprays offer the same active ingredient—oxymetazoline HCl 0.05%—and deliver up to 12 hours of powerful congestion relief. Afrin is the more recognizable name, but Major Nasal Decongestant Spray gives you more product for far less money. The 24-pack offers bulk savings and free shipping, making it ideal for those who need regular relief or want to keep extra bottles on hand.
Whether you’re shopping for personal use, family members, or a small clinic, the smart choice is clear. When comparing Major Nasal Decongestant Spray vs Afrin, you're getting the same results at a fraction of the price—especially when you take advantage of multipack discounts and free shipping at xeteor.com.
Products Mentioned in This Blog Post
Major Nasal Decongestant Spray Oxymetazoline - 1 fl oz | Afrin
$5.99
Major Nasal Decongestant Spray – Compare to Afrin® Major Nasal Decongestant Spray 0.05% delivers powerful, fast-acting relief from nasal congestion—just like Afrin®, but without the...… read more
Major Nasal Decongestant Spray Oxymetazoline - 1 fl oz | Afrin (5 Pack)
$18.95
Major Nasal Decongestant Spray – 1 fl oz (5 Pack) | Compare to Afrin® No Drip Powerful, non-drowsy nasal relief—without the brand-name markup. This 5-pack...… read more
Major Nasal Decongestant Spray Oxymetazoline - 1 fl oz | Afrin (15 Pack)
$48.99
Major Nasal Decongestant Spray – Compare to Afrin® Major Nasal Decongestant Spray 0.05% delivers long-lasting congestion relief without the brand-name price. Each 1 fl oz...… read more
Major Nasal Decongestant Spray Oxymetazoline - 1 fl oz | Afrin (24 Pack)
$69.99
Major Nasal Decongestant Spray Oxymetazoline 0.05% – 1 fl oz | Compare to Afrin® (24 Pack) This 24-pack delivers powerful, pharmacy-grade nasal-congestion relief for less...… read more
Major Nasal Decongestant Spray Oxymetazoline - 0.5 fl oz | Afrin
$5.99
Major Maximum Strength Nasal Decongestant Spray – 0.5 oz Get fast, long-lasting relief from nasal congestion with Major Maximum Strength Nasal Decongestant Spray. This compact...… read more
Major Nasal Decongestant Spray - 0.5 fl oz | Afrin (2 Pack)
$9.99
Major Nasal Decongestant Spray – 12 Hour Relief | 2 Pack Squeeze Bottle Format – Same Medicine, Classic Delivery Can’t breathe through your nose? This...… read more
Major Nasal Decongestant Spray Oxymetazoline - 0.5 fl oz | Afrin (5 Pack)
$17.99
Major Nasal Decongestant Spray – 12 Hour Relief | 5 Pack Waking up congested? This 5-pack of Major Nasal Decongestant Spray (0.5 fl oz each)...… read more
About xeteor.com
xeteor.com, founded in 2018 and based in Las Vegas, Nevada, is an online pharmacy focused on discount over-the-counter (OTC) generic medications and diabetic test strips. We source deals typically reserved for “big pharma” and make them accessible to everyday consumers at wholesale-level prices.
We’re proud to be the #1 authorized online reseller of Major® Pharmaceuticals and Rugby® Laboratories products, as ranked by Trustpilot. With over 8,000 five-star reviews across platforms like Amazon, eBay, Trustpilot, and Google, Xeteor.com is also recognized as a Google Top Quality Store.
Shipping
Orders placed by 3:00 PM PST, Monday–Friday, ship the same day. We offer free nationwide shipping on orders over $30 and on all qualifying Savings Packs. Average delivery time is 3.3 business days. View our full shipping policy here.
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All purchases are backed by our 100-day satisfaction guarantee. Not happy with your order? Return it for free. View our complete return policy here.
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- Email: [email protected]
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Disclaimer: This content is for informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before starting any new supplement or treatment.
FAQs
Is Major Nasal Decongestant Spray the same as Afrin?
Yes. Both products contain the same active ingredient: oxymetazoline hydrochloride 0.05%. They work the same way and provide up to 12 hours of congestion relief.
Why is Major so much cheaper than Afrin?
Major is a generic pharmaceutical brand that doesn’t advertise on TV or run national ad campaigns. You’re paying for the medicine—not the marketing.
Does Major use a pump or squeeze bottle?
The 1 fl oz size uses a pump-style spray. The 0.5 fl oz version comes in a squeeze bottle, which some users prefer for ease of control.
How long does a bottle of nasal spray last?
A 1 fl oz bottle contains about 180 sprays, which lasts roughly 3–4 weeks with typical use. The 0.5 fl oz bottle has around 90 sprays.
Is this safe to use every day?
Only for short-term use. Like Afrin, oxymetazoline sprays should not be used for more than 3 consecutive days, as overuse may lead to rebound congestion.
Is Major Nasal Spray FDA-approved?
Yes. All Major OTC products follow FDA monograph standards and are manufactured in cGMP-certified facilities.
