Colace vs Dulcolax: Which One Should You Take?
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When you're trying to choose between Colace vs Dulcolax, it's important to know they are designed for very different needs. Colace is a gentle stool softener that works over a few days to make bowel movements more comfortable and prevent straining. Dulcolax is a fast-acting stimulant laxative that causes intestinal contractions to provide quick relief, usually overnight. This guide breaks down the key differences to help you decide which is the right choice for your situation.
Quick Comparison: Colace vs Dulcolax
| Feature | Colace | Dulcolax |
|---|---|---|
| Type of Laxative | Stool Softener | Stimulant Laxative |
| Active Ingredient | Docusate Sodium | Bisacodyl |
| Best For | Preventing straining; gentle softening | Fast, predictable relief from constipation |
| Time to Work | 12 to 72 hours | 6 to 12 hours |
How They Work: Stool Softener vs. Stimulant Laxative
The primary difference between Colace and Dulcolax lies in their mechanism of action.
Colace (Docusate Sodium) is a stool softener. It works by increasing the amount of water and fat the stool absorbs in the gut. It doesn't stimulate a bowel movement but instead makes the stool softer and therefore easier and more comfortable to pass. This makes it ideal for individuals who should avoid straining, such as after surgery or for those with hemorrhoids.
Dulcolax (Bisacodyl), on the other hand, is a stimulant laxative. It works by directly stimulating the muscles and nerves of the intestines, which increases contractions and helps push stool through the colon. This direct action results in a much faster and more predictable bowel movement.

Side Effects and Long-Term Safety
Because of their different mechanisms, their side effect profiles also differ. Colace is generally well-tolerated with minimal side effects, which might include mild stomach cramps. It is often considered safe for long-term use when necessary under medical advice.
Dulcolax is more likely to cause side effects like abdominal cramps, diarrhea, nausea, and a sudden sense of urgency. It is designed only for short-term, occasional use. Prolonged use of stimulant laxatives can lead to dependency, where the bowels become reliant on the medication to function.
Saving Money with Generic Colace and Dulcolax
Both Colace and Dulcolax have high-quality, FDA-approved generic versions that offer the same relief at a much lower cost. It's helpful to understand that not all generics are the same; learn more in our guide to Premium vs. Value Generic Drugs.
- For a deep dive into the generic options for Dulcolax, see our complete Guide to Dulcolax Generics.
- Generic docusate sodium (Colace) is available in several forms and sizes. We offer a liquid version for those who prefer it, as well as extra strength 250 mg softgels in a 100-count bottle and a high-value 1000-count bottle. You can also save more with our 2-pack and 5-pack bundles.

Further Reading & Comparisons
For a more detailed look at how these laxatives stack up against other popular over-the-counter options, explore our other comprehensive guides:
- 3-Way Comparison: Miralax vs. Dulcolax vs. Colace – The complete guide to all three major options.
- Miralax vs. Colace – See how a gentle osmotic laxative compares to a stool softener.
- Miralax vs. Dulcolax – Understand the difference between a gentle and a stimulant laxative.
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Disclaimer: This content is for informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before starting any new supplement or treatment.
FAQs
What is the main difference between Colace and Dulcolax?
The main difference is how they work. Colace is a stool softener that works gently over 1-3 days by adding moisture to the stool to make it easier to pass. Dulcolax is a stimulant laxative that works much faster (6-12 hours) by causing the intestinal muscles to contract and force a bowel movement.
Which is better for constipation, Colace or Dulcolax?
Neither is universally "better"—they are for different situations. Choose Colace if your goal is to prevent straining or make bowel movements more comfortable, especially after surgery. Choose Dulcolax if you need fast, predictable relief from an occasional backup.
Can you take Colace and Dulcolax together?
While some doctors may recommend them in combination for specific situations, you should never take them together without consulting a healthcare professional. Combining a stool softener with a stimulant laxative can increase the risk of side effects.
Which one is safer for long-term use?
Colace (Docusate Sodium) is generally considered safe for long-term or daily use as it is non-habit-forming. Dulcolax (Bisacodyl) is designed only for short-term, occasional relief due to the risk of the bowels becoming dependent on it.
Are the generic versions of Colace and Dulcolax the same as the brand?
Yes. Generic Docusate Sodium is medically identical to Colace, and generic Bisacodyl is identical to Dulcolax. They contain the same active ingredients at the same strength and are FDA-approved, offering a more affordable way to get the same relief.